In the pre-PSA-detection era, a large proportion of men were diagnosed with metastatic
prostate cancer and died of the disease; after the introduction of the serum PSA test …

Cancer is the second most common cause of death in the United States, trailing only heart
disease in incidence. Despite significant worldwide investment in research, cancer remains …

Purpose: The summary presented herein covers recommendations on the early detection of
prostate cancer and provides a framework to facilitate clinical decision-making in the …

Abstract Background The European Randomized study of Screening for Prostate Cancer
(ERSPC) has previously demonstrated that prostate-specific antigen (PSA) screening …

Importance Prostate cancer screening remains controversial because potential mortality or
quality-of-life benefits may be outweighed by harms from overdetection and overtreatment …

Summary Background The European Randomised study of Screening for Prostate Cancer
(ERSPC) has shown significant reductions in prostate cancer mortality after 9 years and 11 …

Abstract Context Although prostate cancer (PCa) screening reduces the incidence of
advanced disease and mortality, trade-offs include overdiagnosis and resultant …

Purpose: The guideline purpose is to provide the urologist with a framework for the early
detection of prostate cancer in asymptomatic average risk men. Materials and Methods: A …

Background The current diagnosis of prostate cancer (PCa) uses transrectal ultrasound–
guided biopsy (TRUSGB). TRUSGB leads to sampling errors causing delayed diagnosis …

Importance Prostate cancer screening with the prostate-specific antigen (PSA) test remains
controversial. Objective To review evidence from randomized trials and related modeling …