Enzyme-responsive double-locked photodynamic molecular beacon for targeted photodynamic anticancer therapy

LKB Tam, JCH Chu, L He, C Yang… - Journal of the …, 2023 - ACS Publications
An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in
which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer and a Black Hole …

[HTML][HTML] Orthogonally aligned cyclic BODIPY arrays with long-lived triplet excited states as efficient heavy-atom-free photosensitizers

Z Zhu, X Zhang, X Guo, Q Wu, Z Li, C Yu, E Hao… - Chemical …, 2021 - pubs.rsc.org
In photosensitizers, long triplet excited state lifetimes are key to their efficient electron
transfer or energy transfer processes. Herein, we report a novel class of cyclic trimeric …

Toehold-mediated cascade catalytic assembly for mycotoxin detection and its logic applications

J Pan, F Deng, Z Liu, G Shi, J Chen - Analytical Chemistry, 2022 - ACS Publications
In this work, an enzyme-free biosensor is reported for mycotoxin detection based on a
toehold-mediated catalytic hairpin assembly (CHA) and a DNAzyme-cascaded hydrolysis …

Biogenic fluorescent carbon dots modulated fabrication of concatenate logic library and pattern-mediated molecular keypad lock for chemical sensing application

AM Parambil, MN Mattath, P Rajamani… - Chemical Engineering …, 2023 - Elsevier
In recent years, molecular logic gates (MLGs) have gained much attention among
researchers to replace conventional silicon-based electronic computers. MLGs are …

Dual cathepsin B and glutathione-activated dimeric and trimeric phthalocyanine-based photodynamic molecular beacons for targeted photodynamic therapy

LKB Tam, L Yu, RCH Wong, WP Fong… - Journal of Medicinal …, 2021 - ACS Publications
Two dual stimuli-activated photosensitizers were developed, in which two or three
glutathione (GSH)-responsive 2, 4-dinitrobenzenesulfonate (DNBS)-substituted zinc (II) …

Enzyme activatable photodynamic therapy agents targeting melanoma

I Verirsen, B Uyar, NG Ozsamur, N Demirok… - Organic & …, 2022 - pubs.rsc.org
Cell-selective activity regulation of therapeutics is necessary for efficient personalized
treatments with minimal off-target effects. Here, the first example of a structurally simple …

Cascaded molecular logic gates using antibiotics as inputs based on exonuclease III and DNAzyme

F Deng, J Pan, Z Liu, J Chen - Talanta, 2023 - Elsevier
We successfully constructed several cascaded molecular logic gates (2INHIBIT-2AND,
2AND-2OR, and 2OR-2INHIBIT) using three different antibiotics as the inputs. In the …

A Silicon-Rhodamine-Based Heavy-Atom-Free Photosensitizer for Mitochondria-targeted Photodynamic Therapy

H Zhang, G Ren, W Hou, L Wang, Y Sun… - Spectrochimica Acta Part A …, 2024 - Elsevier
Silicon-xanthene derivatives (SiXs) have gained popularity in the field of bioimaging due to
their advantageous far-red to near-infrared (NIR) absorption and emission wavelengths …

A Tumor‐Targeting Dual‐Stimuli‐Activatable Photodynamic Molecular Beacon for Precise Photodynamic Therapy

LKB Tam, L He, DKP Ng… - … –A European Journal, 2022 - Wiley Online Library
A multifunctional photodynamic molecular beacon (PMB) has been designed and
synthesized which contains an epidermal growth factor receptor (EGFR)‐targeting cyclic …

Glutathione‐Responsive Heterogeneous Metal–Organic Framework Hybrids for Photodynamic‐Gene Synergetic Cell Apoptosis.

J Liu, BJ Córdova Wong, T Liu, H Yang… - … A European Journal, 2022 - search.ebscohost.com
Keywords: biosensors; glutathione; heterogeneous structures; metal-organic frameworks;
singlet oxygen EN biosensors glutathione heterogeneous structures metal-organic …