Substances of unknown or variable composition, complex reaction products, or biological
materials (UVCBs) are over 70 000 “complex” chemical mixtures produced and used at …

Considering the chemical complexity and toxicity data gaps of environmental mixtures, most
studies evaluate the chemical risk individually. However, humans are usually exposed to a …

This paper presents a 10-step read-across (RAX) framework for use in cases where a
threshold of toxicological concern (TTC) approach to cosmetics safety assessment is not …

Heart disease remains a significant human health burden worldwide with a significant
fraction of morbidity attributable to environmental exposures. However, the extent to which …

Per-and polyfluoroalkyl substances (PFAS) are chemicals with important applications; they
are persistent in the environment and may pose human health hazards. Regulatory …

The application of in vitro biological assays as new approach methodologies (NAMs) to
support grouping of UVCB (unknown or variable composition, complex reaction products …

Per-and poly-fluoroalkyl substances (PFAS) are emerging contaminants of concern because
of their wide use, persistence, and potential to be hazardous to both humans and the …

Mineral oil hydrocarbons (MOH) are composed of saturated hydrocarbons (MOSH) and
aromatic hydrocarbons (MOAH). Due to the complexity of the MOH composition, their …

Background: The National Institute of Environmental Health Sciences (NIEHS) continues to
prioritize research to better understand the health effects resulting from exposure to mixtures …

Background Presenting a comprehensive picture of geographic data comprising multiple
factors is an inherently integrative undertaking. Visualizing such data in an interactive form is …