Long noncoding RNAs in cancer: mechanisms of action and technological advancements
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …
being defined as a category of genetic elements, leaving its mark on the field of cancer …
NF-Y in cancer: Impact on cell transformation of a gene essential for proliferation
NF-Y is a ubiquitous heterotrimeric transcription factor with a binding affinity for the CCAAT
consensus motif, one of the most common cis-acting element in the promoter and enhancer …
consensus motif, one of the most common cis-acting element in the promoter and enhancer …
Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients
Background Approaches based on expression signatures of prostate cancer (PCa) have
been proposed to predict patient outcomes and response to treatments. The transcription …
been proposed to predict patient outcomes and response to treatments. The transcription …
The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle
The transcription factor NF-Y promotes cell proliferation and its activity often declines during
differentiation through the regulation of NF-YA, the DNA binding subunit of the complex. In …
differentiation through the regulation of NF-YA, the DNA binding subunit of the complex. In …
[HTML][HTML] Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma
Y Li, X Xiao, H Chen, Z Chen, K Hu… - American Journal of …, 2020 - ncbi.nlm.nih.gov
NFYA (nuclear transcription factor Y, subunit A) is a CCAAT-binding transcription factor.
Accumulating evidence suggests that NFYA plays an important role in breast, ovarian, lung …
Accumulating evidence suggests that NFYA plays an important role in breast, ovarian, lung …
[HTML][HTML] LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition
SK Krönung, U Beyer, ML Chiaramonte, D Dolfini… - Oncotarget, 2016 - ncbi.nlm.nih.gov
A considerable proportion of the human genome consists of transposable elements,
including the long terminal repeats (LTRs) of endogenous retroviruses. During evolution …
including the long terminal repeats (LTRs) of endogenous retroviruses. During evolution …
Xenopus Mcm10 is a CDK-substrate required for replication fork stability
During S phase, following activation of the S phase CDKs and the DBF4-dependent kinases
(DDK), double hexamers of Mcm2-7 at licensed replication origins are activated to form the …
(DDK), double hexamers of Mcm2-7 at licensed replication origins are activated to form the …
[HTML][HTML] An autoregulatory loop controls the expression of the transcription factor NF-Y
The heterotrimeric NF-Y complex is a pioneer factor that binds to CCAAT-genes and
regulates their transcription. NF-Y cooperates with multiple transcription factors and co …
regulates their transcription. NF-Y cooperates with multiple transcription factors and co …
PDGFRβ Activation Induced the Bovine Embryonic Genome Activation via Enhanced NFYA Nuclear Localization
Embryonic genome activation (EGA) is a critical step during embryonic development.
Several transcription factors have been identified that play major roles in initiating EGA; …
Several transcription factors have been identified that play major roles in initiating EGA; …
[HTML][HTML] NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription
The expression of the high risk HPV18 E6 and E7 oncogenic proteins induces the
transformation of epithelial cells, through the disruption of p53 and Rb function. The binding …
transformation of epithelial cells, through the disruption of p53 and Rb function. The binding …