[HTML][HTML] Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives

A Mafi, H Rismanchi, Y Gholinezhad… - Frontiers in …, 2023 - frontiersin.org
Leukaemia is a dangerous malignancy that causes thousands of deaths every year
throughout the world. The rate of morbidity and mortality is significant despite many …

The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review

C Pivonello, M Negri, R Patalano, F Amatrudo… - Obesity …, 2022 - Wiley Online Library
Obesity is a chronic condition whose management is a critical challenge for physicians. The
scientific community has increased its focus on the molecular mechanisms involved in …

Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport

J Florido, L Martinez‐Ruiz… - Journal of pineal …, 2022 - Wiley Online Library
The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS)
levels, but how melatonin induces this ROS generation is unknown. In the present study, we …

Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression

YW Yen, YL Lee, LY Yu, CE Li, PW Shueng… - International Journal of …, 2023 - Elsevier
Melatonin and fucoidan are naturally active compounds that have been reported to have
therapeutic benefits for patients receiving cancer treatment. However, both compounds face …

[HTML][HTML] Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy …

L Wang, C Wang, X Li, Z Tao, W Zhu, Y Su… - Cellular & Molecular …, 2023 - Springer
Background Oral squamous cell carcinomas are one of the most common cancers
worldwide with aggressive behavior and poor prognosis. Reactive oxygen species (ROS) …

Effect of sub-lethal ammonia and nitrite stress on autophagy and apoptosis in hepatopancreas of Pacific whiteleg shrimp Litopenaeus vannamei

S Yang, J Luo, Y Huang, Y Yuan, S Cai - Fish & Shellfish Immunology, 2022 - Elsevier
Oxidative stress caused by ammonia and nitrite, affect the health and growth of aquaculture
animals, results in oxidative damages. However, the toxic mechanism and pathogenesis of …

Pan‐Cancer analyses reveal Genomics and clinical characteristics of the Melatonergic regulators in cancer

J Zhang, H Jiang, K Du, T Xie, B Wang… - Journal of pineal …, 2021 - Wiley Online Library
Melatonin, an endogenous hormone, plays protective roles in cancer. In addition to
regulating circadian rhythms, sleep, and neuroendocrine activity, melatonin functions in …

Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects

A Bagherifard, A Hosseinzadeh, F Koosha… - Osteoporosis …, 2023 - Springer
Purpose Bone diseases account for an enormous cost burden on health systems. Bone
disorders are considered as age-dependent diseases. The aging of world population has …

Protective and therapeutic potential of melatonin against intestinal diseases: updated review of current data based on molecular mechanisms

S Mehrzadi, M Sheibani, F Koosha… - Expert Review of …, 2023 - Taylor & Francis
Introduction Intestinal diseases, a leading global cause of mortality and morbidity, carry a
substantial socioeconomic burden. Small and large intestines play pivotal roles in …

Crosstalk between aging, circadian rhythm, and melatonin

AK Verma, MI Khan, F Ashfaq, SI Rizvi - Rejuvenation Research, 2023 - liebertpub.com
Circadian rhythms (CRs) are 24-hour periodic oscillations governed by an endogenous
circadian pacemaker located in the suprachiasmatic nucleus (SCN), which organizes the …