Overcoming skin barriers through advanced transdermal drug delivery approaches

V Phatale, KK Vaiphei, S Jha, D Patil, M Agrawal… - Journal of controlled …, 2022 - Elsevier
Upon exhaustive research, the transdermal drug delivery system (TDDS) has appeared as a
potential, well-accepted, and popular approach to a novel drug delivery system. Ease of …

In vitro blood brain barrier models: An overview

E Jagtiani, M Yeolekar, S Naik, V Patravale - Journal of Controlled Release, 2022 - Elsevier
Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …

3D skin models along with skin-on-a-chip systems: A critical review

W Sun, Z Liu, J Xu, Y Cheng, R Yin, L Ma, H Li… - Chinese Chemical …, 2023 - Elsevier
Skin is the largest organ in human body, and it plays an important role in regulating
physiological microenvironments and acts as a barrier to protect human body from harmful …

[HTML][HTML] Journey of organ on a chip technology and its role in future healthcare scenario

D Singh, A Mathur, S Arora, S Roy… - Applied Surface Science …, 2022 - Elsevier
Organ on a chip refers to microengineered biomimetic system which reflects structural and
functional characteristics of human tissue. It involves biomaterial technology, cell biology …

Development of skin-on-a-chip platforms for different utilizations: Factors to be considered

J Ponmozhi, S Dhinakaran, Z Varga-Medveczky… - Micromachines, 2021 - mdpi.com
There is increasing interest in miniaturized technologies in diagnostics, therapeutic testing,
and biomedicinal fundamental research. The same is true for the dermal studies in topical …

Structural and functional analysis of excised skins and human reconstructed epidermis with confocal Raman spectroscopy and in microfluidic diffusion chambers

D Kocsis, H Kichou, K Döme, Z Varga-Medveczky… - Pharmaceutics, 2022 - mdpi.com
Several ex vivo and in vitro skin models are available in the toolbox of dermatological and
cosmetic research. Some of them are widely used in drug penetration testing. The excised …

Models for barrier understanding in health and disease in lab-on-a-chips

J Ponmozhi, S Dhinakaran, D Kocsis, K Iván… - Tissue …, 2024 - Taylor & Francis
The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction
of these barriers can lead to various pathological processes, including increased exposure …

Skin-on-a-chip technology for testing transdermal drug delivery—starting points and recent developments

Z Varga-Medveczky, D Kocsis, MB Naszlady, K Fónagy… - Pharmaceutics, 2021 - mdpi.com
During the last decades, several technologies were developed for testing drug delivery
through the dermal barrier. Investigation of drug penetration across the skin can be …

Skin-on-a-chip technologies towards clinical translation and commercialization

N Ismayilzada, C Tarar, SR Dabbagh, BK Tokyay… - …, 2024 - iopscience.iop.org
Skin is the largest organ of the human body which plays a critical role in thermoregulation,
metabolism (eg synthesis of vitamin D), and protection of other organs from environmental …

Development and evaluation of a human skin equivalent in a semiautomatic microfluidic diffusion chamber

J Tárnoki-Zách, E Mehes, Z Varga-Medveczky, DG Isai… - Pharmaceutics, 2021 - mdpi.com
There is an increasing demand for transdermal transport measurements to optimize topical
drug formulations and to achieve proper penetration profile of cosmetic ingredients …