Potassium tert-butoxide mediated C–C, C–N, C–O and C–S bond forming reactions

J Madasu, S Shinde, R Das, S Patel… - Organic & Biomolecular …, 2020 - pubs.rsc.org
Potassium tertiary butoxide (KOtBu) mediated constructions of C–C, C–O, C–N, and C–S
bonds are reviewed with special emphasis on their synthetic applications. KOtBu can be …

Strategies towards the synthesis of anti-tuberculosis drugs

HB Rode, DM Lade, R Grée, PS Mainkar… - Organic & …, 2019 - pubs.rsc.org
Antituberculosis drugs have captured the attention of the scientific community due to the
emergence of drug resistance. Hence, the development of new analogs and new drugs …

Accessing polysubstituted quinazolines via nickel catalyzed acceptorless dehydrogenative coupling

S Parua, R Sikari, S Sinha, G Chakraborty… - The Journal of …, 2018 - ACS Publications
Two environmentally benign methods for the synthesis of quinazolines via acceptorless
dehydrogenative coupling of 2-aminobenzylamine with benzyl alcohol (Path A) and 2 …

KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines

T Ghosh, S Jana, J Dash - Organic letters, 2019 - ACS Publications
This work discloses transamidation of primary and tertiary amides with a range of aryl,
heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at …

Selective hydrogenation of nitriles to primary amines by using a cobalt phosphine catalyst

R Adam, CB Bheeter, JR Cabrero‐Antonino… - …, 2017 - Wiley Online Library
A general procedure for the catalytic hydrogenation of nitriles to primary amines by using a
non‐noble metal‐based system is presented. Co (acac) 3 in combination with tris [2 …

Sulfonium Salt Reagents for the Introduction of Deuterated Alkyl Groups in Drug Discovery

K Ban, K Imai, S Oyama, J Tokunaga… - Angewandte …, 2023 - Wiley Online Library
The pharmacokinetics of pharmaceutical drugs can be improved by replacing C− H bonds
with the more stable C− D bonds at the α‐position to heteroatoms, which is a typical …

Visible-Light-Promoted Transition-Metal-Free Phosphinylation of Heteroaryl Halides in the Presence of Potassium tert-Butoxide

J Yuan, WP To, ZY Zhang, CD Yue, S Meng… - Organic …, 2018 - ACS Publications
A novel visible-light-promoted C–P bond formation reaction in the absence of both transition
metal and photoredox catalysts is disclosed. By employing easily available and inexpensive …

Atom-Economical and Tandem Conversion of Nitriles to N-Methylated Amides Using Methanol and Water

B Paul, M Maji, S Kundu - ACS Catalysis, 2019 - ACS Publications
A cobalt complex catalyzed tandem conversion of nitrile to N-methylated amide is described
using a methanol and water mixture. Using this protocol, several nitriles were directly and …

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors

I Khelifi, T Naret, D Renko, A Hamze, G Bernadat… - European journal of …, 2017 - Elsevier
The synthesis and evaluation of a new series of IsoCombretaQuinolines (IsoCoQuines) 2
with a 2-substituted-quinoline in place of the 3, 4, 5-trimethoxyphenyl ring present in isoCA-4 …

[图书][B] Practical synthetic organic chemistry: reactions, principles, and techniques

S Caron - 2020 - books.google.com
Diese Publikation ist ein Praktikerbuch für Organiker. Der Schwerpunkt liegt auf den
Reaktionen, die am verlässlichsten und nützlichsten sind. Die Autoren der einzelnen Kapitel …