Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

Apoptosis, the cell-suicide programme executed by caspases, is critical for maintaining
tissue homeostasis, and impaired apoptosis is now recognized to be a key step in …

Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a
few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of …

Puma encodes a BH3-only protein that is induced by the p53 tumor suppressor and other
apoptotic stimuli. To assess its physiological role in apoptosis, we generated Puma knockout …

Cell death is regulated mainly through an evolutionarily conserved form of cell suicide
termed apoptosis [1]. Deregulation of apoptosis has been associated with cancer …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …

Interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor regulate the
survival, proliferation, and differentiation of hematopoietic lineages. Phosphatidylinositol 3 …

A paradox for the cancer biology field has been the revelation that oncogenes, once thought
to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. Myc is …

The transcription factor GATA-1 is essential for normal erythropoiesis. By examining in vitro–
differentiated embryonic stem cells, we showed previously that in the absence of GATA-1 …