Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by
excessive scarring, which leads to increased tissue stiffness, loss in lung function and …

Progressive fibrosis in the kidney, liver, lung, heart, bone marrow, and skin is both a major
cause of suffering and death and an important contributor to the cost of health care. All of this …

Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its
biological role has not been elucidated in detail. Here we show that biglycan acts in …

Muscle Injuries and Repair: Current Trends in Research : JBJS Muscle Injuries and Repair:
Current Trends in Research : JBJS JBJS Journal Case Connector Reviews JBJS.org Surgical …

In this article, we review the biology and physiological importance of transforming growth
factor-β (TGF-β) to homeostasis in the respiratory system, its importance to innate and …

Nonrheumatic aortic stenosis of trileaflet aortic valves has been considered to be a
“degenerative” process, but the early lesion of aortic stenosis contains the chronic …

Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril
formation, and therefore important for the proper formation of extracellular matrices. SLRPs …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

The Transforming Growth Factor β superfamily (TGFβ) is one of the most complex groups of
cytokines with widespread effects on many aspects of growth and development. The TGFβ …