Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair.
However, both too little and too much vitamin A has deleterious effects. Retinoic acid and …

Human prenatal skin is populated by innate immune cells, including macrophages, but
whether they act solely in immunity or have additional functions in morphogenesis is …

Understanding the cellular and molecular determinants of mammalian tissue regeneration
and repair is crucial for developing effective therapies that restore tissue architecture and …

Organ regeneration requires dynamic cell interactions to reestablish cell numbers and tissue
architecture. While we know the identity of progenitor cells that replace lost tissue, the …

Background Microglia are tissue resident macrophages with a wide range of critically
important functions in central nervous system development and homeostasis. Method In this …

Impaired angiogenesis, bacterial infection, persistent severe pain, exacerbated
inflammation, and oxidative stress injury are intractable problems in the treatment of chronic …

Dermal fibroblasts lose stem cell potency after birth, which prevents regenerative healing.
However, the underlying intracellular mechanisms are largely unknown. We uncover the …

Mesenchymal stem cells (MSCs) are an ideal seed cell for tissue engineering and stem cell
transplantation. MSCs combined with biological scaffolds play an important role in …

Effective skin wound healing is a complex process involving anti‐inflammation, fibrosis,
matrix reconstruction, and angiogenesis. This work aimed to integrate the macrophage …

As a population of homogeneous cells with both self-renewal and differentiation potential,
stem cell pools are highly compartmentalized and contain distinct subsets that exhibit stable …