The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Since the identification of matrix metalloproteinases (MMPs), a family of zinc-dependent
endopeptidases, as being a driving factor for cancer progression and patient prognosis …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the
extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs or …

The purpose of this review is to highlight the recent mechanistic developments elucidating
the role of matrix metalloproteinases (MMPs) in tumour invasion and metastasis. The ability …

Epidermal growth factor receptor (EGFR) overexpression is common in head and neck
squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been …

Abstract Since Gross and Lapiere firstly discovered matrix metalloproteinases (MMPs) as
important collagenolytic enzymes during amphibian tadpole morphogenesis in 1962, this …

Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …