Cocaine-induced gene regulation in D1 and D2 neuronal ensembles of the nucleus accumbens revealed by single-cell RNA sequencing

P Mews, AVA Mason, EG Kirchner, M Estill, EJ Nestler - bioRxiv, 2024 - biorxiv.org
Cocaine use disorder is characterized by persistent drug-seeking behavior and a high risk of
relapse, driven by lasting molecular and circuit adaptations in the nucleus accumbens. To …

[HTML][HTML] Integrative multi-dimensional characterization of striatal projection neuron heterogeneity in adult brain

J Gayden, S Puig, C Srinivasan, BDN Phan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Striatal projection neurons (SPNs) are traditionally segregated into two subpopulations
expressing dopamine (DA) D 1-like or D 2-like receptors. However, this dichotomy is …