Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

In the modern era of advanced technologies, rapid and accurate analyses are needed, both
for scientific research and for industrial applications. For this reason, the Surface Plasmon …

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Efforts to therapeutically target EZH2 have generally focused on inhibition of its
methyltransferase activity, although it remains less clear whether this is the central …

Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-
related death. A subset of castration-resistant prostate cancers become androgen receptor …

Amplification of MYCN is the driving oncogenic change in a subset of high-risk
neuroblastomas. The MYCN protein and the Aurora-A kinase form a complex during the S …

High-intensity transcription and replication supercoil DNA to levels that can impede or halt
these processes. As a potent transcription amplifier and replication accelerator, the proto …