Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

Focal iron accumulation associated with brain iron dyshomeostasis is a pathological
hallmark of various neurodegenerative diseases (NDD). The application of iron-sensitive …

The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Copper is an essential trace element, and plays a vital role in numerous physiological
processes within the human body. During normal metabolism, the human body maintains …

The copper compound CuII (atsm) has progressed to phase 2/3 testing for treatment of the
neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII (atsm) is …

Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons in the
central nervous system (CNS). Mutations in the metalloenzyme SOD1 are associated with …

Since the first description of Parkinson's disease (PD) over two centuries ago, the
recognition of rare types of atypical parkinsonism has introduced a spectrum of related PD …

Physiologic roles of copper in metabolic homeostasis have been well established; however,
whether and how copper is dysregulated in tumors and contributes to tumorigenesis is not …

The blood–brain barrier permeant, copper-containing compound, CuII (atsm), has
successfully progressed from fundamental research outcomes in the laboratory through to …

Disrupted copper availability in the central nervous system (CNS) is implicated as a
significant feature of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) …