The role of molecular autopsy in unexplained sudden cardiac death

DJ Tester, MJ Ackerman - Current opinion in cardiology, 2006 - journals.lww.com
With autopsy-negative SUD accounting for a significant number of sudden deaths in young
people, a new role for the medical examiner is emerging. An accurate diagnosis, derived …

Sudden cardiac death with normal heart:: molecular autopsy

C Basso, E Carturan, K Pilichou, S Rizzo… - Cardiovascular …, 2010 - Elsevier
Several culprits may be identified at postmortem in sudden death (SD) victims, including
coronary artery, myocardial, valve, conduction system, and congenital heart diseases …

Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance

RE Eckart, EA Shry, AP Burke, JA McNear… - Journal of the American …, 2011 - jacc.org
Objectives: The purpose of this study was to define the incidence and characterization of
cardiovascular cause of sudden death in the young. Background: The epidemiology of …

Cardiac channel molecular autopsy: insights from 173 consecutive cases of autopsy-negative sudden unexplained death referred for postmortem genetic testing

DJ Tester, A Medeiros-Domingo, ML Will… - Mayo Clinic …, 2012 - Elsevier
Objective To perform long QT syndrome and catecholaminergic polymorphic ventricular
tachycardia cardiac channel postmortem genetic testing (molecular autopsy) for a large …

Postmortem long QT syndrome genetic testing for sudden unexplained death in the young

DJ Tester, MJ Ackerman - Journal of the American College of Cardiology, 2007 - jacc.org
Objectives: This study sought to determine the spectrum and prevalence of long QT
syndrome (LQTS)-associated mutations in a large cohort of autopsy-negative sudden …

Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's …

DJ Tester, DB Spoon, HH Valdivia, JC Makielski… - Mayo Clinic …, 2004 - Elsevier
OBJECTIVE To perform a molecular autopsy of the RyR2-encoded cardiac ryanodine
receptor/calcium release channel in medical examiner/coroner's cases of sudden …

Molecular autopsy: Twenty years of post-mortem diagnosis in sudden cardiac death

E Martínez-Barrios, S Grassi, M Brión, R Toro… - Frontiers in …, 2023 - frontiersin.org
In the forensic medicine field, molecular autopsy is the post-mortem genetic analysis
performed to attempt to unravel the cause of decease in cases remaining unexplained after …

Molecular autopsy of sudden cardiac death in the genomics era

V Castiglione, M Modena, A Aimo, E Chiti, N Botto… - Diagnostics, 2021 - mdpi.com
Molecular autopsy is the process of investigating sudden death through genetic analysis. It
is particularly useful in cases where traditional autopsy is negative or only shows non …

The molecular autopsy: should the evaluation continue after the funeral?

DJ Tester, MJ Ackerman - Pediatric cardiology, 2012 - Springer
Sudden cardiac death (SCD) is one of the most common causes of death in developed
countries, with most SCDs involving the elderly, and structural heart disease evident at …

Molecular genetics of sudden cardiac death

MS Rodríguez-Calvo, M Brion, C Allegue… - Forensic science …, 2008 - Elsevier
Sudden cardiac death (SCD) is one of the most common causes of death. An important
number of sudden deaths, especially in the young, are due to genetic heart disorders, both …