Current developments of coumarin compounds in medicinal chemistry
XM Peng, G LV Damu, C He Zhou - Current pharmaceutical …, 2013 - benthamdirect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …
Coumarins as antioxidants
Coumarins, a well-known class of naturally occurring compounds, display a remarkable
array of biochemical and pharmacological actions, some of which suggest that certain …
array of biochemical and pharmacological actions, some of which suggest that certain …
Recent advances in the synthesis of coumarin derivatives via Knoevenagel condensation: A review
RH Vekariya, HD Patel - Synthetic Communications, 2014 - Taylor & Francis
The synthesis of coumarins through Knoevenagel condensation is one of the most important
processes in synthetic organic chemistry and medicinal chemistry. Compounds including a …
processes in synthetic organic chemistry and medicinal chemistry. Compounds including a …
Coumarin hybrid derivatives as promising leads to treat tuberculosis: Recent developments and critical aspects of structural design to exhibit anti-tubercular activity
Tuberculosis (TB) is a highly contagious airborne disease with nearly 25% of the world's
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …
Antagonists of vitamin K—popular coumarin drugs and new synthetic and natural coumarin derivatives
K Kasperkiewicz, MB Ponczek, J Owczarek, P Guga… - Molecules, 2020 - mdpi.com
Many natural coumarins and their chemically synthesized analogs and derivatives exert
diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with …
diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with …
Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant
activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited …
activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited …
Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives
A series of novel coumarin bisindole heterocycles were synthesized following an uncommon
method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model …
method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model …
Natural dibenzo-α-pyrones and their bioactivities
Z Mao, W Sun, L Fu, H Luo, D Lai, L Zhou - Molecules, 2014 - mdpi.com
Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi,
mycobionts, plants and animal feces. They exhibit a variety of biological activities such as …
mycobionts, plants and animal feces. They exhibit a variety of biological activities such as …
Coumarin hybrids for targeted therapies: A promising approach for potential drug candidates
NM Zeki, YF Mustafa - Phytochemistry Letters, 2024 - Elsevier
Phyto-coumarins demonstrate diverse biological actions, encompassing antiradical, anti-
inflammatory, oncolytic, monoamine oxidase B (MAOB) suppression, and antibacterial …
inflammatory, oncolytic, monoamine oxidase B (MAOB) suppression, and antibacterial …
Synthesis of coumarin-thioether conjugates as potential anti-tubercular agents: Their molecular docking and X-ray crystal studies
In this work, we report a series of 4-(2, 6-dimethylphenyl) thio) methyl)-2H-chromen-2-one
conjugates as promising leads to treat tuberculosis. Spectroscopic and other analytical …
conjugates as promising leads to treat tuberculosis. Spectroscopic and other analytical …