Sequence-Evolution-Function is an introduction to the computational approaches that play a
critical role in the emerging new branch of biology known as functional genomics. The book …

The Omega class of cytosolic glutathione transferases was initially recognized by
bioinformatic analysis of human sequence databases, and orthologous sequences were …

The spliced alignment of expressed sequence data to genomic sequence has proven a key
tool in the comprehensive annotation of genes in eukaryotic genomes. A novel algorithm …

Prior evidence has supported the existence of multiple susceptibility genes for
schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we …

Usher syndrome type I (USH1) is an autosomal recessive disorder characterized by
congenital sensorineural hearing loss, vestibular dysfunction and visual impairment due to …

We have collected over half a million splice sites from five species—Homo sapiens, Mus
musculus, Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana …

Genomic sequences and expressed sequence tag data for a diverse group of fungi
(Saccharomyces cerevisiae, Schizosaccharomyces pombe, Aspergillus nidulans …

BACKGROUND: Lamin A/C mutations are a well-established cause of dilated
cardiomyopathy (DCM), although their frequency has not been examined in a large cohort of …

Persistent infections with high-risk human papillomaviruses (HPVs) induce dysplastic
lesions of the lower genital tract. Some of these lesions eventually progress to invasive …

It has been previously observed that the intrinsically weak variant GC donor sites, in order to
be recognized by the U2-type spliceosome, possess strong consensus sequences …