Homologous recombination and DNA repair are important for genome maintenance.
Genetic variations in essential homologous recombination genes, including BRCA1 and …

Two related tumor suppressor genes, BRCA1 and BRCA2, attract a lot of attention from both
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …

Germline BRCA1 mutation carriers face a high breast cancer risk; however, the underlying
mechanisms for this risk are not completely understood. Using a new genetically engineered …

MammaPrint®(MP) is a 70‐gene signature that stratifies early‐stage breast cancer patients
into low‐and high risk of distant relapse. Further stratification of MP risk results identifies four …

DNA repair is a vital mechanism in cells that protects against DNA damage caused by
internal and external factors. It involves a network of signaling pathways that monitor and …

The interplay between genes harboring single nucleotide polymorphisms (SNPs) is vital to
better understand underlying contributions to the etiology of breast cancer. Much attention …

High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component,
only half of which is explained. Previously, we performed germline exome sequencing on …

Mutations in the BRCA1 and BRCA2 genes are known risk factors and drivers of breast and
ovarian cancers. So far, few studies have been focused on understanding the differences in …

Motivation Recent advances in DNA sequencing technologies have allowed the detailed
characterization of genomes in large cohorts of tumors, highlighting their extreme …

Fewer DNA mutations have been identified in pediatric tumors than in adult tumors,
suggesting that alternative tumorigenic mechanisms, including aberrant DNA methylation …