Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …

Polycomb group (PcG) proteins maintain transcriptional repression during development,
likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of …

The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

An enormous body of work generated over the past three decades has revealed that
eukaryotic gene transcription is a remarkably intricate biochemical process that is tightly …

In eukaryotes, the genes encoding ribosomal RNAs (rDNA) exist in two distinct epigenetic
states that can be distinguished by a specific chromatin structure that is maintained …

PARP-1 is the most abundantly expressed member of a family of proteins that catalyze the
transfer of ADP-ribose units from NAD+ to target proteins. Herein, we describe previously …

Numerous post-translational modifications of histones have been described in organisms
ranging from yeast to humans. Growing evidence for dynamic regulation of these …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …