A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches
Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …
health problems across the lifespan. Increasing evidence supports the hypothesis that …
Understanding resilience and preventing and treating PTSD
Resilience is defined as the dynamic ability to adapt successfully in the face of adversity,
trauma, or significant threat. Some of the key early studies of resilience were observational …
trauma, or significant threat. Some of the key early studies of resilience were observational …
Traumatic stress and accelerated DNA methylation age: a meta-analysis
Background Recent studies examining the association between posttraumatic stress
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
Recent genetics and epigenetics approaches to PTSD
Abstract Purpose of Review Following a life-threatening traumatic exposure, about 10% of
those exposed are at considerable risk for developing posttraumatic stress disorder (PTSD) …
those exposed are at considerable risk for developing posttraumatic stress disorder (PTSD) …
The effects of trauma, with or without PTSD, on the transgenerational DNA methylation alterations in human offsprings
Exposure to psychological trauma is a strong risk factor for several debilitating disorders
including post-traumatic stress disorder (PTSD) and depression. Besides the impact on …
including post-traumatic stress disorder (PTSD) and depression. Besides the impact on …
A review of epigenetic contributions to post-traumatic stress disorder
H Howie, CM Rijal, KJ Ressler - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Post-traumatic stress disorder (PTSD) is a syndrome which serves as a classic example of
psychiatric disorders that result from the intersection of nature and nurture, or gene and …
psychiatric disorders that result from the intersection of nature and nurture, or gene and …
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
Accelerating research on biological aging and mental health: Current challenges and future directions
Aging is associated with complex biological changes that can be accelerated, slowed, or
even temporarily reversed by biological and non-biological factors. This article focuses on …
even temporarily reversed by biological and non-biological factors. This article focuses on …
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and …
Epigenetic factors modify the effects of environmental factors on biological outcomes.
Identification of epigenetic changes that associate with PTSD is therefore a crucial step in …
Identification of epigenetic changes that associate with PTSD is therefore a crucial step in …
The correlation of methylation levels measured using Illumina 450K and EPIC BeadChips in blood samples
Aim: We examined concordance of methylation levels across the Illumina Infinium
HumanMethylation450 BeadChip and the Infinium MethylationEPIC BeadChip. Methods …
HumanMethylation450 BeadChip and the Infinium MethylationEPIC BeadChip. Methods …