Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Inhibition of poly (ADP-ribose) polymerase (PARP) activity induces synthetic lethality in
mutated BRCA1/2 cancers by selectively targeting tumor cells that fail to repair DNA double …

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa
protein. BARD1 displays a dual role in cancer development and progression as it acts as a …

Background Colorectal cancer (CRC) represents a major cause of cancer deaths worldwide.
Although significant progress has been made by molecular and immune therapeutic …

RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …

Simple Summary Defective DNA damage response (DDR) is a hallmark of cancer leading to
genomic instability. Up to 15–20% of colorectal cancers carry alterations in DDR. However …

DNA damage response, a key factor involved in maintaining genome integrity and stability,
consists of several kinase-dependent signaling pathways, which sense and transduce DNA …