[HTML][HTML] When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …
developing many different age-associated diseases, including cancer, cardiovascular …
Branched-chain amino acids in cardiovascular disease
RW McGarrah, PJ White - Nature Reviews Cardiology, 2023 - nature.com
Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …
The circadian biology of heart failure
Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the
suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly …
suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly …
Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism
ME Trautman, NE Richardson, DW Lamming - Aging cell, 2022 - Wiley Online Library
The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …
world, and creative solutions are needed to promote healthy longevity. Recent work has …
[HTML][HTML] BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice
E Bollinger, M Peloquin, J Libera, B Albuquerque… - Molecular …, 2022 - Elsevier
Objective Branched chain amino acid (BCAA) catabolic defects are implicated to be causal
determinates of multiple diseases. This work aimed to better understand how enhancing …
determinates of multiple diseases. This work aimed to better understand how enhancing …
Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury
S Dolci, L Mannino, E Bottani, A Campanelli… - Pharmacological …, 2022 - Elsevier
Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the
damaged tissue suffers from a severe metabolic impairment, which aggravates axonal …
damaged tissue suffers from a severe metabolic impairment, which aggravates axonal …
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
RJ Roth Flach, E Bollinger, AR Reyes… - Nature …, 2023 - nature.com
Branched chain amino acid (BCAA) catabolic impairments have been implicated in several
diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step …
diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step …
Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart
Circadian disruption increases cardiovascular disease (CVD) risk, through poorly
understood mechanisms. Given that small RNA species are critical modulators of cardiac …
understood mechanisms. Given that small RNA species are critical modulators of cardiac …
Circadian rhythms in cardiovascular metabolism
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …
Circadian influences on myocardial ischemia-reperfusion injury and heart failure
T Eckle, J Bertazzo, TN Khatua… - Circulation …, 2024 - Am Heart Assoc
The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …
established, with numerous studies in genetically modified animals emphasizing the …