Simple Summary Glioblastoma is one of the most treatment-refractory human malignancies,
and despite techniques that have allowed scientists and clinicians to better understand the …

Abstract T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy
used for the treatment of several advanced forms of cancer. Work using TCR-engineered T …

Immune cells in the tumor microenvironment regulate cancer growth. Thus cancer
progression is dependent on the activation or repression of transcription programs involved …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

Oncogene-induced STAT3-activation is central to tumor progression by promoting cancer
cell expression of pro-angiogenic and immunosuppressive factors. STAT3 is also activated …

Despite the important evolution of immunotherapeutic agents, brain tumors remain, in
general, refractory to immune therapeutics. Recent discoveries have revealed that the …

The study of immune evasion has gained a well-deserved eminence in cancer research by
successfully developing a new class of therapeutics, immune checkpoint inhibitors, such as …

Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through
the accumulation of cellular senescence. The senescent cells burden in WAT has been …

The three major conventional treatments: surgery, chemotherapy, and radiation therapy,
have been commonly performed for lung cancer. However, lung cancer is still the leading …

Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell
biology has attracted considerable attention in the immunology community. Long-term …