Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors
Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …
[HTML][HTML] Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells
N Dark, MV Cosson, LI Tsansizi, TJ Owen, E Ferraro… - Cell Reports …, 2023 - cell.com
Decreased left ventricle (LV) function caused by genetic mutations or injury often leads to
debilitating and fatal cardiovascular disease. LV cardiomyocytes are, therefore, a potentially …
debilitating and fatal cardiovascular disease. LV cardiomyocytes are, therefore, a potentially …
Advancements in techniques for human iPSC-derived cardiomyocytes maturation: mechanical and electrical stimulation approaches
The maturation of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-
CMs) is pivotal for their potent application in regenerative medicine, drug screening, and …
CMs) is pivotal for their potent application in regenerative medicine, drug screening, and …
Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification
T Somers, S Siddiqi, RGC Maas, JPG Sluijter… - Basic Research in …, 2024 - Springer
Statins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting
cholesterol synthesis. These effects are primarily beneficial for the patient's vascular system …
cholesterol synthesis. These effects are primarily beneficial for the patient's vascular system …
Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
M te Lintel Hekkert, G Newton, K Chapman… - Basic Research in …, 2021 - Springer
Reducing infarct size (IS) by interfering with mechanisms for cardiomyocyte death remains
an elusive goal. DMX-5804, a selective inhibitor of the stress-activated kinase MAP4K4 …
an elusive goal. DMX-5804, a selective inhibitor of the stress-activated kinase MAP4K4 …
Investigation into the difference in mitochondrial-cytosolic calcium coupling between adult cardiomyocyte and hiPSC-CM using a novel multifunctional genetic probe
Ca 2+ cycling plays a critical role in regulating cardiomyocyte (CM) function under both
physiological and pathological conditions. Mitochondria have been implicated in Ca 2+ …
physiological and pathological conditions. Mitochondria have been implicated in Ca 2+ …
The Dynamic Clamp Technique: A Robust Toolkit for Investigating Potassium Channel Function
C Bartolucci, L Sala - Potassium Channels: Methods and Protocols, 2024 - Springer
The dynamic clamp technique has emerged as a powerful tool in the field of cardiac
electrophysiology, enabling researchers to investigate the intricate dynamics of ion currents …
electrophysiology, enabling researchers to investigate the intricate dynamics of ion currents …
[PDF][PDF] Gunnar Weninger1, 2, 3, 9, Tatiana Pochechueva1, 2, 3, Dana El Chami1, 2, 3, Xiaojing Luo6
C Lenz, SE Lehnart - Scientific Reports, 2022 - academia.edu
Results Characterization of JP2 fragmentation products following Calpain‑1 or Calpain‑2
proteoly‑sis. Previously, immunoblotting against different JP2 epitopes or fusion tagging …
proteoly‑sis. Previously, immunoblotting against different JP2 epitopes or fusion tagging …
Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling
B Svobodova, S Jelinkova, M Pesl, D Beckerová… - … -European Journal of …, 2021 - Springer
Duchenne muscular dystrophy is a genetic disorder where an X-linked mutation in the DMD
gene initiates pathogenic development caused by the absence of dystrophin protein. This …
gene initiates pathogenic development caused by the absence of dystrophin protein. This …
Biophysical Stretch Induced Differentiation and Maturation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
J Qin, A van Mil, JPG Sluijter - Cardiac Mechanobiology in Physiology and …, 2023 - Springer
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a
compelling alternative to primary CMs, which assisted in modeling cardiovascular disease …
compelling alternative to primary CMs, which assisted in modeling cardiovascular disease …