During the past few years, proteomics has been extensively applied to various fields of
medicine including nephrology. Current applications of renal and urinary proteomics are to …

Owing to its availability, ease of collection, and correlation with pathophysiology of diseases,
urine is an attractive source for clinical proteomics. However, many proteomic studies have …

Urinary biomarkers for diabetes, diabetic nephropathy, and nondiabetic proteinuric renal
diseases were sought. For 305 individuals, biomarkers were defined and validated in …

OBJECTIVE—Diabetic nephropathy is a serious complication of both type 1 and type 2
diabetes, and, unless arrested, leads to end-stage renal disease. Current diagnosis consists …

Fibrosis is the common endpoint and currently the best predictor of progression of chronic
kidney diseases (CKDs). Despite several drawbacks, biopsies remain the only available …

One third of patients with type 1 diabetes and microalbuminuria experience an early,
progressive decline in renal function that leads to advanced stages of chronic kidney …

From its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its
designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical …

Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on
kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of …

Aims: The lack of early biomarkers for acute renal failure (ARF) has crippled our ability to
launch potentially effective therapeutic measures. We tested the hypothesis that urinary …

Urinary proteins may provide clues regarding pathogenesis of kidney disease as well as
providing markers of disease activity. We employed two‐dimensional differential in‐gel …