Multiple myeloma (MM) is a hematological malignancy, which remains incurable because
most patients eventually relapse or become refractory to current treatments. Due to …

The stem cell paradigm was first demonstrated in hematopoietic stem cells. Whilst classically
it was cytokines and chemokines which were believed to control stem cell fate, more recently …

Breast cancer has become one of the most common dreadful diseases that target women
across the globe. The most obvious reasons we associate with it are either genetic …

Featured Application Targeting interaction between sonic hedgehog protein and sex
hormone receptors might be a valuable strategy for the treatment of endocrine-resistant …

Background: Hedgehog signaling pathway is a developmental pathway mostly inactive in
adult tissues, with the exception of stem cells. It is often found upregulated in various tumors …

PTCH1 gene codes for a 12-pass transmembrane receptor with a negative regulatory role in
the Hedgehog-Gli signaling pathway. PTCH1 germline mutations cause Gorlin syndrome, a …

IntroductIon Normal and tumor cells use many pathways for survival, proliferation and
communication with environment. Many defects during lifetime occur and consequently …

Acute myeloid leukaemia (AML) encompasses a group of aggressive haematological
neoplasms. It is a cancer stem cell (CSC) disorder. The Hedgehog (Hh) signalling pathway …

Sažetak Serozni karcinomi jajnika najčešći su oblik epitelnih tumora jajnika. Uglavnom se
dijagnosticiraju u uznapredovalom stadiju bolesti i imaju visoku stopu smrtnosti. Kod raka …

PTCH1 gene is one of the main members of the Hedgehog-Gli signaling pathway. In the
5'untranslated region (5'UTR) of PTCH1 transcript 1b, a CGG-repeat polymorphism was …