Intracellular bacterial pathogens pose significant public health challenges due to their ability
to evade immune defenses and conventional antibiotics. Drug repurposing has recently …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is a global health
concern, affecting millions worldwide. This bacterium has earned a reputation as a …

Accurate identification of potential drug–target interactions (DTIs) is a crucial task in drug
development and repositioning. Despite the remarkable progress achieved in recent years …

Trimethoprim (TMP) and sulfonamides and are typically utilized to hinder the activities of
dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes …

Serotogenic toxicity is a major hurdle associated with Linezolid in the treatment of drug-
resistant tuberculosis (TB) due to the inhibition of monoamine oxidase (MAO) enzymes …

Introduction Tuberculosis (TB), particularly its drug-resistant forms (MDR-TB and XDR-TB),
continues to pose a significant global health challenge. Despite advances in treatment and …

The tuberculosis (TB) emergency has been a pressing health threat for decades. With the
emergence of drug-resistant TB and complications from the COVID-19 pandemic, the TB …

Mycobacterium tuberculosis (M. tb) remains a formidable global health threat. The
increasing drug resistance among M. tb clinical isolates is exacerbating the current …

Background Drug repurposing offers a strategic alternative to the development of novel
compounds, leveraging the known safety and pharmacokinetic profiles of medications, such …

BTZ043 is an 8-nitro-1, 3-benzothiazin-4-one with potency against multidrug-resistant
Mycobacterium tuberculosis. Low solubility and hepatic metabolism are linked to poor oral …