A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …
onset—remains an important public health need. Prior studies have developed genome …
Genomic innovation in early life cardiovascular disease prevention and treatment
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally.
Although CVD events do not typically manifest until older adulthood, CVD develops …
Although CVD events do not typically manifest until older adulthood, CVD develops …
Genome-wide risk prediction of common diseases across ancestries in one million people
Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk
Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across
the life course; a key benefit over short-term prediction models. To produce risk estimates …
the life course; a key benefit over short-term prediction models. To produce risk estimates …
Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases
Polygenic risk scores (PRSs) are an emerging tool to predict the clinical phenotypes and
outcomes of individuals. We propose PRSmix, a framework that leverages the PRS corpus …
outcomes of individuals. We propose PRSmix, a framework that leverages the PRS corpus …
A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease
Polygenic scores (PGS) for coronary heart disease (CHD) are constructed using GWAS
summary statistics for CHD. However, pleiotropy is pervasive in biology and disease …
summary statistics for CHD. However, pleiotropy is pervasive in biology and disease …
Integration of biomarker polygenic risk score improves prediction of coronary heart disease
There are several established biomarkers for coronary heart disease (CHD), including blood
pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined …
pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined …
Integrating common risk factors with polygenic scores improves the prediction of type 2 diabetes
Y Timasheva, Z Balkhiyarova, D Avzaletdinova… - International journal of …, 2023 - mdpi.com
We tested associations between 13 established genetic variants and type 2 diabetes (T2D)
in 1371 study participants from the Volga-Ural region of the Eurasian continent, and …
in 1371 study participants from the Volga-Ural region of the Eurasian continent, and …
Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations
Background Cardiovascular diseases (CVD) are a major health concern in Africa. Improved
identification and treatment of high-risk individuals can reduce adverse health outcomes …
identification and treatment of high-risk individuals can reduce adverse health outcomes …
Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population
M Brīvība, I Atava, R Pečulis, I Elbere, L Ansone… - International Journal of …, 2024 - mdpi.com
Numerous type 2 diabetes (T2D) polygenic risk scores (PGSs) have been developed to
predict individuals' predisposition to the disease. An independent assessment and …
predict individuals' predisposition to the disease. An independent assessment and …