Health repercussions of environmental exposure to lead: Methylation perspective

SS Shiek, MS Mani, SP Kabekkodu, HS Dsouza - Toxicology, 2021 - Elsevier
Lead (Pb) exposure has been a major public health concern for a long time now due to its
permanent adverse effects on the human body. The process of lead toxicity has still not been …

Mitochondrial DNA mutagenesis: feature of and biomarker for environmental exposures and aging

TC Leuthner, JN Meyer - Current environmental health reports, 2021 - Springer
Abstract Purpose of Review Mitochondrial dysfunction is a hallmark of aging. Mitochondrial
genome (mtDNA) instability contributes to mitochondrial dysfunction, and mtDNA …

[HTML][HTML] Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: in vivo and liver organoids …

W Cheng, H Chen, Y Zhou, Y You, D Lei, Y Li… - Environment …, 2024 - Elsevier
Ageing is a nature process of microplastics that occurrs daily, and human beings are
inevitably exposed to aged microplastics. However, a systematic understanding of ageing …

Oxidative stress genes define two subtypes of triple-negative breast cancer with prognostic and therapeutic implications

S Liu, H Xu, Y Feng, UD Kahlert, R Du… - Frontiers in …, 2023 - frontiersin.org
Introduction: Oxidative stress (OS)-related genes have been confirmed to be closely related
to the prognosis of triple-negative breast cancer (TNBC) patients; despite this fact, there is …

Lead exposure induces metabolic reprogramming in rat models

MS Mani, MB Joshi, RR Shetty, VL DSouza, M Swathi… - Toxicology Letters, 2020 - Elsevier
Lead is a toxin of great public health concern affecting the young and aging population.
Several factors such as age, gender, lifestyle, dose, and genetic makeup result in …

Impacts of PFOAC8, GenXC6, and their mixtures on zebrafish developmental toxicity and gene expression provide insight about tumor-related disease

H Liu, Y Chen, W Hu, Y Luo, P Zhu, S You, Y Li… - Science of The Total …, 2023 - Elsevier
Concerns about per-and polyfluoroalkyl substances (PFASs) have grown in importance in
the fields of ecotoxicology and public health. This study aims to compare the potential effects …

Discovery of a Novel Shared Variant Among RTEL1 Gene and RTEL1-TNFRSF6B lncRNA at Chromosome 20q13.33 in Familial Progressive Myoclonus Epilepsy

S Chaudhari, LP Acharya, DB Jasti… - … Journal of Genomics, 2024 - Wiley Online Library
Background: Progressive myoclonus epilepsy (PME) is a neurodegenerative disorder
marked by recurrent seizures and progressive myoclonus. To date, based on the …

Exposure to arsenic and lead in children from Salamanca México, effects on telomeric lengthening and mitochondrial DNA

JA Alegría-Torres, RY Pérez-Rodríguez… - … Science and Pollution …, 2020 - Springer
Levels of urinary arsenic and levels of lead in blood were measured in children attending
elementary schools located in an industrial zone in Salamanca, México. Its possible effects …

Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy

R Naha, A Anees, S Chakrabarty, PS Naik, M Pandove… - Mitochondrion, 2020 - Elsevier
Abstract Intrauterine Growth Restriction (IUGR) is a common and significant complication
that arises during pregnancy wherein the fetus fails to attain its full growth potential …

Associations of blood lead levels with multiple genotoxic biomarkers among workers in China: A population-based study

T Wang, Y Tu, K Wang, S Gong, G Zhang, Y Zhang… - Environmental …, 2021 - Elsevier
Carcinogenic effects from low doses of lead (Pb) exposure to populations have been
suspected but not concluded. Therefore, a large-scale cross-sectional study was conducted …