Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Collagens are the most abundant proteins in the extracellular matrix. They provide a
framework to build organs and tissues and give structural support to make them resistant to …

Organ fibrosis is characterized by epithelial injury and aberrant tissue repair, where
activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen …

The transcription variation, leading to various forms of transcripts and protein diversity,
remains largely unexplored in triple-negative breast cancers (TNBCs). Here, we presented a …

The hallmark of fibrosis is an excessive accumulation of collagen, ultimately leading to
organ failure. It has become evident that the deposited collagen also exhibits qualitative …

Tumor progression is marked by dense collagenous matrix accumulations that dynamically
reorganize to accommodate a growing and invasive tumor mass. Cancer-associated …

Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet,
the molecular underpinnings and therapeutic implications of this feature remain unclear …

Epidermolysis bullosa (EB), the paradigm of heritable skin fragility disorders, is associated
with mutations in as many as 20 distinct genes. One of the clinical variants, recessive …

Collagen is the most abundant protein in mammals. A unique feature of collagen is its triple-
helical structure formed by the Gly-Xaa-Yaa repeats. Three single chains of procollagen …