Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …

Previous studies showed a low-grade enterovirus infection in the pancreatic islets of patients
with newly diagnosed type 1 diabetes (T1D). In the Diabetes Virus Detection (DiViD) …

Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in
insulin deficiency and type 1 diabetes (T1D),,–. Certain enteroviruses can infect β cells in …

Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk.
Genetic risk scores (GRS), which facilitate the integration of complex genetic information …

Enterovirus-induced infection of the central nervous system (CNS) results in acute
inflammation of the brain (encephalitis) and constitutes a significant global burden to human …

Importance The incidence of diabetes in childhood has increased during the COVID-19
pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity …