Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Intracellular recordings in vivo have shown that neocortical neurons are subjected to an
intense synaptic bombardment in intact networks and are in a'high-conductance'state. In …

The extent to which neocortical pyramidal cells function as a local network is determined by
the strength and probability of their connections. By mapping connections between …

Half a century since their discovery by Llinás and colleagues, dendritic spikes have been
observed in various neurons in different brain regions, from the neocortex and cerebellum to …

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied
neuron types in the mammalian neocortex and has become a benchmark for understanding …

The integrative properties of dendrites are determined by a complex mixture of factors,
including their morphology, the spatio-temporal patterning of synaptic inputs, the balance of …

Neurons receive thousands of synaptic inputs throughout elaborate dendritic trees. Here we
determine the somatic impact of excitatory postsynaptic potentials (EPSPs) generated at …

How effective are synaptic inputs made at different dendritic sites in the control of action
potential output? Recent technical advances have allowed direct observation of the …

Dendrites integrate inputs nonlinearly, but it is unclear how these nonlinearities contribute to
the overall input-output transformation of single neurons. We developed statistically …

We provide a functional measure, the synaptic information efficacy (SIE), to assess the
impact of synaptic input on spike output. SIE is the mutual information shared by the …