A better understanding of COVID-19 in people with primary immunodeficiency (PI), rare
inherited defects in the immune system, is important for protecting this population, especially …

We review the characteristics of SARS-CoV-2 infection in a large number of patients with IEI.
Overall, we found that combined immunodeficiencies, immune dysregulation disorders, and …

Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …

Purpose There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of
Immunity (IEI) and many unresolved questions. We aimed to describe the clinical outcome of …

Since the arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
December 2019, its characterization as a novel human pathogen, and the resulting …

Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune
host defense and immunoregulation. Considering the predisposition to develop severe and …

Despite the progress in the understanding how COVID-19 infection may impact
immunocompromised patients, the data on inborn errors of immunity (IEI) remain limited and …

Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN)
established a registry of cases to collate the outcomes of individuals with PID and SID …

The clinical evolution of patients infected with the Severe Acute Respiratory Coronavirus
type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The …

The analysis of rare cases of severe COVID-19, coupled with assessing the impact of SARS-
CoV2 infection in individuals with previously diagnosed IEI, has revealed fundamental …