Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases
Aging is linked to the deterioration of many physical and cognitive abilities and is the leading
risk factor for Alzheimer's disease. The growing aging population is a significant healthcare …
risk factor for Alzheimer's disease. The growing aging population is a significant healthcare …
Translational control in cell ageing: an update
K Woodward, NE Shirokikh - Biochemical Society Transactions, 2021 - portlandpress.com
Cellular ageing is one of the main drivers of organismal ageing and holds keys towards
improving the longevity and quality of the extended life. Elucidating mechanisms underlying …
improving the longevity and quality of the extended life. Elucidating mechanisms underlying …
⍺-Synuclein levels in Parkinson's disease–Cell types and forms that contribute to pathogenesis
Parkinson's disease (PD) has two main pathological hallmarks, the loss of nigral dopamine
neurons and the proteinaceous aggregations of⍺-synuclein (⍺ Syn) in neuronal Lewy …
neurons and the proteinaceous aggregations of⍺-synuclein (⍺ Syn) in neuronal Lewy …
A top‐down proteomic approach reveals a salivary protein profile able to classify Parkinson's disease with respect to Alzheimer's disease patients and to healthy …
C Contini, L Fadda, G Lai, C Masala, A Olianas… - …, 2024 - Wiley Online Library
Parkinson's disease (PD) is a complex neurodegenerative disease with motor and non‐
motor symptoms. Diagnosis is complicated by lack of reliable biomarkers. To individuate …
motor symptoms. Diagnosis is complicated by lack of reliable biomarkers. To individuate …
Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy
F Dick, GAS Johanson, OB Tysnes, G Alves… - Molecular …, 2024 - Springer
The molecular pathogenesis of degenerative parkinsonisms, including Parkinson's disease
(PD), progressive supranuclear palsy (PSP), and Multiple system atrophy (MSA), remains …
(PD), progressive supranuclear palsy (PSP), and Multiple system atrophy (MSA), remains …
Translation is an emerging constraint on protein homeostasis in ageing
J Llewellyn, SJ Hubbard, J Swift - Trends in Cell Biology, 2024 - cell.com
Proteins are molecular machines that provide structure and perform vital transport, signalling
and enzymatic roles. Proteins expressed by cells require tight regulation of their …
and enzymatic roles. Proteins expressed by cells require tight regulation of their …
The potential therapeutic strategy in combating neurodegenerative diseases: Focusing on natural products
L Gao, XN Yang, YX Dong, YJ Han, XY Zhang… - Pharmacology & …, 2024 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and Multiple sclerosis (MS) …
Amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and Multiple sclerosis (MS) …
Recent pharmacological insights on abating toxic protein species burden in neurological disorders: Emphasis on 26S proteasome activation
Protein homeostasis (proteostasis) refers to the plethora of mechanisms that safeguard the
proper folding of the newly synthesized proteins. It entails various intricately regulated cues …
proper folding of the newly synthesized proteins. It entails various intricately regulated cues …
Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain
D Di Fraia, A Marino, JH Lee, EK Sacramento… - …, 2024 - pmc.ncbi.nlm.nih.gov
Aging and neurodegeneration entail diverse cellular and molecular hallmarks. Here, we
studied the effects of aging on the transcriptome, translatome, and multiple layers of the …
studied the effects of aging on the transcriptome, translatome, and multiple layers of the …