The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely
expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates …

Regulating transcription allows organisms to respond to their environment, both within a
single generation (plasticity) and across generations (adaptation). We examined …

Protein expression evolves under greater evolutionary constraint than mRNA levels, and
translation efficiency represents a primary determinant of protein levels during stimuli …

The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated
oncogenic pathway in triple-negative breast cancer (TNBC), a highly aggressive tumor …

Background Critically ill patients with sepsis and acute respiratory distress syndrome have
severely altered physiology and immune system modifications. RNA splicing is a basic …

Background Acute respiratory distress syndrome (ARDS) remains a common organ
dysfunction in the critically ill patient. Mechanisms for its development have focused on …

Fetal neural stem cells (FNSCs) present in the human fetal brain differentiate into cells of
neuronal and glial lineages. The developing fetus is exposed to lower oxygen …

Abstract HNRNPA2B1 and HNRNPR stabilize ASCL1 mRNA in neuroblastoma, but whether
their regulatory effects depend on m6A modification and whether their function involves …

Background Vasculogenic mimicry (VM) is an enigmatic physiological feature that influences
blood supply within glioblastoma (GBM) tumors for their sustained growth. Previous studies …

Neuroblastoma, the major cause of infant cancer deaths, results from fast proliferation of
undifferentiated neuroblasts. Treatment of high-risk neuroblastoma includes differentiation …