The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

The design of constrained peptides is of prime importance in the development of bioactive
compounds and for applications in supramolecular chemistry. Due to its nature, the peptide …

HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids
during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays …

Peptides that are composed of an alternating pattern of α-and γ-amino acids are potentially
valuable as metabolism-resistant bioactive agents. For optimal function, some kind of …

Conformational analysis of γ-peptides composed of 4, 4-gem-dimethyl γ-amino acids, their
spontaneous self-assembly into nanofibrillar superstructures and remarkable …

Antimicrobial peptides (AMPs) are promising antibacterial agents often hindered by their
undesired hemolytic activity. Inspired by gramicidin S (GS), a well‐known cyclodecapeptide …

Original αγα tripeptides containing one β, γ-diamino acid have been synthesized and their
conformation determined by extensive NMR and molecular dynamic studies. These studies …

The conformational preferences of helix foldamers have been studied in oligo-γ-peptides
composed of 2-aminocyclopentylacetic acid (γAc5a) with a cyclopentyl constraint on the Cβ …

We have recently reported the synthesis of enantiomerically pure CF3-oxazolidine
pseudoprolines (CF3-ΨPro). Complete NMR studies, together with DFT calculations, have …

Using a β, γ-diamino acid, several small hybrid α/γ peptides have been synthesized and
their conformations investigated through extensive NMR studies and molecular dynamics. A …