RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …

As the up-and-comer in the development of RNA nanotechnology, RNA nanomaterials
based on functionalized rolling circle transcription (RCT) have become promising carriers for …

Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic
hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused …

miRNAs are short noncoding RNA single strands, with a crucial role in several biological
processes. miRNAs are dysregulated in several human diseases, and their detection is an …

MicroRNAs are small ribonucleotides that act as key gene regulators. Their altered
expression is often associated with the onset and progression of several human diseases …

Protein–RNA interactions are integral to the biological functions of RNA. It is well recognized
that molecular dynamics (MD) simulations of protein–RNA complexes are more challenging …

Phosphorothioates (PTs) are important chemical modifications of the RNA backbone where
a single nonbridging oxygen of the phosphate is replaced with a sulfur atom. PT can …

We present here an innovative modular and outsourced model of drug research and
development for microRNA oligonucleotide therapeutics (miRNA ONTs). This model is being …

Conformational dynamics play a crucial role in determining the behavior of the
biomolecules. Polarizable force fields, such as AMOEBA, can accurately capture …

G-quadruplexes (GQs) are four-stranded noncanonical DNA and RNA architectures that can
be formed by guanine-rich sequences. The stability of GQs increases with the number of G …