At least five muscarinic receptors genes have been cloned and expressed. Muscarinic receptors act via activation of G proteins: m1, m3 and m5 muscarinic receptors couple to …
NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing lifespans and better medical treatment for other conditions mean that the prevalence of this …
MM Mesulam, C Geula - Journal of Comparative Neurology, 1988 - Wiley Online Library
The nucleus basalis (NB) of the human brain is a large, complex, and highly differentiated structure. Many of its neurons are magnocellular, hyperchromic, isodendritic …
M Mesulam - Learning & memory, 2004 - learnmem.cshlp.org
A profound loss of cortical cholinergic innervation is a nearlyinvariant feature of advanced Alzheimer's disease (AD). The temporal course of this lesion and its relationship to other …
AH Rezvani, ED Levin - Biological psychiatry, 2001 - Elsevier
Nicotine and other nicotinic agonists have been found to improve performance on attention and memory tasks. Clinical studies using nicotine skin patches have demonstrated the …
The common marmoset (Callithrix jacchus) has been valuable as a primate model in biomedical research. Interest in this species has grown recently, in part due to the successful …
ED Levin, BB Simon - Psychopharmacology, 1998 - Springer
Nicotinic cholinergic systems are involved with several important aspects of cognitive function including attention, learning and memory. Nicotinic cholinergic receptors are …
SJ Allen, D Dawbarn - Clinical science, 2006 - portlandpress.com
The neurotrophins are growth factors required by discrete neuronal cell types for survival and maintenance, with a broad range of activities in the central and peripheral nervous …
Organophosphate (OP)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by OP …