Key Points Genetics of Chronic Kidney Disease Genetic causes of chronic kidney disease
(CKD) are not uncommon. Patients with CKD should be referred for genetic consultation and …

Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Background Studies have documented AKI with high-grade proteinuria in patients with
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In some patients …

Rationale & Objective Kidney biopsy data inform us about pathologic processes associated
with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We …

Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …

Rates of many types of severe kidney disease are much higher in Black individuals than
most other ethnic groups. Much of this disparity can now be attributed to genetic variants in …

HIV-positive individuals are at increased risk for kidney disease, including HIV-associated
nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney …