The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in
drug design processes. Significant attention has been directed at obtaining molecules …

Organoselenium compounds have been successfully applied in biological, medicinal and
material sciences, as well as a powerful tool for modern organic synthesis, attracting the …

The importance and prevalance of O-, N-, and S-atom containing saturated four-membered
ring motifs in biologically active molecules and potential therapeutics continues to drive …

A facile and efficient method for the diastereo/regioselective synthesis of highly
functionalized spiro-oxetane oxindoles has been described. The 1, 8-diazabicyclo [5.4. 0] …

The review covers the results of studies published in the literature on the synthesis of spiro‐
linked heterocycles of the indole, quinoline, benzoxazine, benzothiazine …

In recent years, vinyl selenones were rediscovered as useful building blocks for new
synthetic transformations. This review will highlight these advances in the field of multiple …

A three-component synthesis of novel spirooxindole-tetrahydropyrrolizines from secondary α-
aminoacids, isatins and vinyl selenones has been disclosed. Products were formed in good …

Spiro-heterocycles garner much fascination due to their unique conformational features and
vast biological applications than simple heterocycles. The number of spirocyclic scaffolds …

An important issue to discover biological structures is the design of sustainable, safe, clean,
cost-effective, excellent efficient synthetic reactions, and minimal energy consumption to …