Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone
deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively …

Fluoride is a natural element essential in minute quantities in human's to maintain dental
and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride …

Rationale: Traditional treatments for leukemia fail to address stem cell drug resistance
characterized by epigenetic mediators such as histone lysine-specific demethylase 4 …

Fluoride is commonly consider as a “double-edged sword” because low consumption of
fluoride can effectively prevent dental caries, but excessive consumption of fluoride can …

Aims Lung aging results in altered lung function, reduced lung remodeling and regenerative
capacity, and increased susceptibility to acute and chronic lung diseases. The molecular …

Excess fluoride in drinking water is an environmental issue of increasing worldwide concern,
because of its adverse effect on human health. Skeletal fluorosis caused by chronic …

Gastric cancer (GC) is one of the most common cancers around the world. Searching for
specific gene expression changes during the development of GC could help identify …

Abstract DNA topoisomerase II (TOP2) is an enzyme that performs a critical function in
manipulating DNA topology during replication, transcription, and chromosomal compaction …

The trace element fluoride can be beneficial for oral health by preventing dental caries.
However, fluoride is also known as an environmental pollutant. Fluoride pollution can lead …

Excess consumption of fluoride during the development of tooth enamel will cause dental
fluorosis, but the exact molecular mechanisms remain to be elucidated. Circadian rhythm is …