Autism spectrum disorder (ASD) has a complex genetic architecture involving contributions
from both de novo and inherited variation. Few studies have been designed to address the …

Advanced paternal age is associated with an increased risk of fathering children with
genetic disorders and other adverse reproductive consequences. However, the mechanisms …

Background Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous
group of neurodevelopmental disorders. Despite the extensive efforts of scientists, the …

The complexity of autism's phenotypic spectra is well-known, yet most genetic research uses
case-control status as the target trait. It is undetermined if autistic symptom domain severity …

Autism sibling recurrence in prospective infant family history studies is~ 20% at 3 years but
systematic follow‐up to mid‐childhood is rare. In population and clinical cohorts autism is …

Evidence suggests autistic individuals at elevated familial likelihood of autism spectrum
disorder (by virtue of having an autistic sibling) have stronger cognitive abilities on average …

T-Box Brain Transcription Factor 1 (TBR1) plays essential roles in brain development,
mediating neuronal migration, fate specification, and axon tract formation. While …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in communication, diminished social skills, and restrictive and repetitive behaviors and …

Exonic variants present some of the strongest links between genotype and phenotype.
However, these variants can have significant inter-individual pathogenicity differences …

Autism is a neurodevelopmental condition with a range of symptoms that vary in intensity
and severity from person to person. Genetic sequencing has identified thousands of genes …