Promising therapeutic targets for treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
The non-coding RNA interactome in joint health and disease
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment
Y Sun, J Zhao, Q Wu, Y Zhang, Y You… - npj Regenerative …, 2022 - nature.com
Osteoarthritis (OA) is the leading cause of disability worldwide. Considerable progress has
been made using stem-cell-derived therapy. Increasing evidence has demonstrated that the …
been made using stem-cell-derived therapy. Increasing evidence has demonstrated that the …
[PDF][PDF] MiR-34a-5p inhibits fibroblast-like synoviocytes proliferation via XBP1.
AF Song, L Kang, YF Wang… - European Review for …, 2020 - europeanreview.org
OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune, inflammatory disease mainly
manifested by joint damage. Its mechanism is not completely clear at present. Previous …
manifested by joint damage. Its mechanism is not completely clear at present. Previous …
Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms
M Li, F Tian, J Guo, X Li, L Ma, M Jiang… - Frontiers in …, 2023 - frontiersin.org
Arthritis is a common degenerative disease of joints, which has become a public health
problem affecting human health, but its pathogenesis is complex and cannot be eradicated …
problem affecting human health, but its pathogenesis is complex and cannot be eradicated …
Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis
J Wang, X Kong, H Hu, S Shi - Journal of orthopaedic surgery and …, 2020 - Springer
Background Rheumatoid arthritis (RA), a kind of autoimmune disorder, is featured by many
physical symptoms and proliferation of fibroblast-like synoviocytes (FLSs). The relevance of …
physical symptoms and proliferation of fibroblast-like synoviocytes (FLSs). The relevance of …
[HTML][HTML] miR-145-5p inhibits psoriasis progression by regulating the Wnt/β-catenin pathway
Y Wang, Y Cao - American journal of translational research, 2021 - ncbi.nlm.nih.gov
Objective: This research aimed to probe into the effect of miR-145-5p in psoriasis by
regulating Wnt/β-catenin. Methods: A total of 45 psoriasis patients treated in our hospital …
regulating Wnt/β-catenin. Methods: A total of 45 psoriasis patients treated in our hospital …
Circ_0003972 promotes the proliferation and inflammation of fibroblast-like synovial cells in rheumatoid arthritis through regulation of the miR-654-5p/FZD4 Axis
J Li, D Liu, K Wu, Q Chen, J Lei - Immunological Investigations, 2022 - Taylor & Francis
ABSTRACT Background Circular RNAs (circRNAs) have been shown to play an important
role in rheumatoid arthritis (RA) progression. This study aims to explore the role and …
role in rheumatoid arthritis (RA) progression. This study aims to explore the role and …
Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy
MB Senthilkumar, P Sarangi, S Amit, S Senguttuvan… - Thrombosis …, 2023 - Elsevier
Hemophilic arthropathy (HA) due to repeated bleeding into the joint cavity is a major cause
of morbidity in patients with hemophilia. The molecular mechanisms contributing to this …
of morbidity in patients with hemophilia. The molecular mechanisms contributing to this …
Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in …
X Geng, C Zhao, Z Zhang, Y Liu, X Zhang, P Ding - Autoimmunity, 2022 - Taylor & Francis
Background The function and pathological significance of circular RNAs (circRNAs) in
autoimmune diseases, such as rheumatoid arthritis (RA), are barely known. Here, we …
autoimmune diseases, such as rheumatoid arthritis (RA), are barely known. Here, we …