Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs

G Bolla, B Sarma, AK Nangia - Chemical reviews, 2022 - ACS Publications
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Conformational polymorphism

AJ Cruz-Cabeza, J Bernstein - Chemical reviews, 2014 - ACS Publications
The century following the determination of the first crystal structure by the Braggs 1 has
yielded encyclopedic precise information on molecular geometry. The interatomic distances …

Crystal engineering: from molecule to crystal

GR Desiraju - Journal of the American Chemical Society, 2013 - ACS Publications
How do molecules aggregate in solution, and how do these aggregates consolidate
themselves in crystals? What is the relationship between the structure of a molecule and the …

Advanced crystallisation methods for small organic molecules

JP Metherall, RC Carroll, SJ Coles, MJ Hall… - Chemical Society …, 2023 - pubs.rsc.org
Molecular materials based on small organic molecules often require advanced structural
analysis, beyond the capability of spectroscopic techniques, to fully characterise them. In …

How many more polymorphs of ROY remain undiscovered

GJO Beran, IJ Sugden, C Greenwell, DH Bowskill… - Chemical …, 2022 - pubs.rsc.org
With 12 crystal forms, 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophenecabonitrile (aka ROY)
holds the current record for the largest number of fully characterized organic crystal …

Frontiers of molecular crystal structure prediction for pharmaceuticals and functional organic materials

GJO Beran - Chemical Science, 2023 - pubs.rsc.org
The reliability of organic molecular crystal structure prediction has improved tremendously in
recent years. Crystal structure predictions for small, mostly rigid molecules are quickly …

[HTML][HTML] Photo, thermal and chemical degradation of riboflavin

MA Sheraz, SH Kazi, S Ahmed… - Beilstein Journal of …, 2014 - beilstein-journals.org
Riboflavin (RF), also known as vitamin B 2, belongs to the class of water-soluble vitamins
and is widely present in a variety of food products. It is sensitive to light and high …

Conformational polymorphism in organic crystals

A Nangia - Accounts of chemical research, 2008 - ACS Publications
Polymorphs are different crystalline modifications of the same chemical substance. When
different conformers of the same molecule occur in different crystal forms, the phenomenon …

Polymorphism in molecular solids: an extraordinary system of red, orange, and yellow crystals

L Yu - Accounts of chemical research, 2010 - ACS Publications
Diamond and graphite are polymorphs of each other: they have the same composition but
different structures and properties. Many other substances exhibit polymorphism: inorganic …

ROY reclaims its crown: new ways to increase polymorphic diversity

A Levesque, T Maris, JD Wuest - Journal of the American …, 2020 - ACS Publications
Chemical compounds that exist in multiple crystalline forms are said to exhibit
polymorphism. Polymorphs have the same composition, but their structures and properties …