Simulating nature in sperm selection for assisted reproduction

ETY Leung, CL Lee, X Tian, KKW Lam, RHW Li… - Nature Reviews …, 2022 - nature.com
Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000
sperm out of millions in an ejaculate reach the fallopian tube and thus have a chance of …

Gamete-mediated mate choice: towards a more inclusive view of sexual selection

J Kekäläinen, JP Evans - Proceedings of the Royal …, 2018 - royalsocietypublishing.org
'Sperm competition'—where ejaculates from two or more males compete for fertilization—
and 'cryptic female choice'—where females bias this contest to suit their reproductive …

Perfluoro-octanoic acid impairs sperm motility through the alteration of plasma membrane

I Šabović, I Cosci, L De Toni, A Ferramosca… - Journal of …, 2020 - Springer
C ontext Perfluoroalkyl-substances (PFAS) are chemical additives considered harmful for
humans. We recently showed that accumulation of perfluoro-octanoic acid (PFOA) in human …

Sperm selection in the female mammalian reproductive tract. Focus on the oviduct: hypotheses, mechanisms, and new opportunities

WV Holt, A Fazeli - Theriogenology, 2016 - Elsevier
Research over the past 3 decades has caused a major shift in the way that the oviduct, or
fallopian tube, is perceived. Previously, it was regarded as little more than the anatomic site …

Role of zinc trafficking in male fertility: from germ to sperm

C Foresta, A Garolla, I Cosci, M Menegazzo… - Human …, 2014 - academic.oup.com
STUDY QUESTION What are the dynamics of zinc (Zn) trafficking in sperm, at the testicular,
epididymal and ejaculate levels? SUMMARY ANSWER Zn transporters are peculiarly …

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis

P Caballero‐Campo, MG Buffone… - Journal of cellular …, 2014 - Wiley Online Library
Although recent evidence indicates that several chemokines and defensins, well‐known as
inflammatory mediators, are expressed in the male and female reproductive tracts, the …

Ovulation and extra-ovarian origin of ovarian cancer

Y Yang-Hartwich, M Gurrea-Soteras, N Sumi, WD Joo… - Scientific reports, 2014 - nature.com
The mortality rate of ovarian cancer remains high due to late diagnosis and recurrence. A
fundamental step toward improving detection and treatment of this lethal disease is to …

Do sperm possess a molecular passport? Mechanistic insights into sperm selection in the female reproductive tract

WV Holt, A Fazeli - MHR: Basic science of reproductive …, 2015 - academic.oup.com
Most male mammals produce far more spermatozoa on a daily basis than is strictly
necessary for reproduction and females have evolved mechanisms that prevent all but a …

Heat sensing receptor TRPV1 is a mediator of thermotaxis in human spermatozoa

L De Toni, A Garolla, M Menegazzo, S Magagna… - PloS one, 2016 - journals.plos.org
The molecular bases of sperm thermotaxis, the temperature-oriented cell motility, are
currently under investigation. Thermal perception relies on a subclass of the transient …

Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies

S Soto-Heras, D Sakkas, DJ Miller - Biology of reproduction, 2023 - academic.oup.com
The contribution of sperm to embryogenesis is gaining attention with up to 50% of infertility
cases being attributed to a paternal factor. The traditional methods used in assisted …