Pathobiology of Modic changes
Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …
Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its …
BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations
L Manchikanti, S Abdi, S Atluri, RM Benyamin… - Pain …, 2013 - search.proquest.com
OBJECTIVE: To develop evidence-based clinical practice guidelines for interventional
techniques in the diagnosis and treatment of chronic spinal pain. METHODOLOGY …
techniques in the diagnosis and treatment of chronic spinal pain. METHODOLOGY …
The association between obesity and low back pain: a meta-analysis
R Shiri, J Karppinen, P Leino-Arjas… - American journal of …, 2010 - academic.oup.com
This meta-analysis assessed the association between overweight/obesity and low back
pain. The authors systematically searched the Medline (National Library of Medicine …
pain. The authors systematically searched the Medline (National Library of Medicine …
Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort
FPS Mok, D Samartzis, J Karppinen, DYT Fong… - The spine journal, 2016 - Elsevier
Abstract Background Context Modic changes (MC) are bone marrow lesions on magnetic
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …
Body mass index as a risk factor for developing chronic low back pain: a follow-up in the Nord-Trøndelag Health Study
I Heuch, I Heuch, K Hagen, JA Zwart - Spine, 2013 - journals.lww.com
Study Design. A population-based, prospective cohort study. Objective. To determine
whether overweight, obesity, or more generally an elevated body mass index (BMI) increase …
whether overweight, obesity, or more generally an elevated body mass index (BMI) increase …
ISSLS prize winner: vertebral endplate (Modic) change is an independent risk factor for episodes of severe and disabling low back pain
JH Määttä, S Wadge, A MacGregor, J Karppinen… - Spine, 2015 - journals.lww.com
Study Design. Longitudinal cohort study of twins representative of the general population.
Objective. To assess the relationship between Modic change (MC) and severe, disabling …
Objective. To assess the relationship between Modic change (MC) and severe, disabling …
Severe lumbar intervertebral disc degeneration is associated with modic changes and fatty infiltration in the paraspinal muscles at all lumbar levels, except for L1-L2: a …
EE Özcan-Ekşi, MŞ Ekşi, MA Akçal - World neurosurgery, 2019 - Elsevier
Background Low back pain is a common public health problem associated with lumbar
intervertebral disc degeneration. It is still unclear, however, whether intervertebral disc …
intervertebral disc degeneration. It is still unclear, however, whether intervertebral disc …
Refined phenotyping of Modic changes: imaging biomarkers of prolonged severe low back pain and disability
JH Määttä, J Karppinen, M Paananen, C Bow… - Medicine, 2016 - journals.lww.com
Low back pain (LBP) is the world's most disabling condition. Modic changes (MC) are
vertebral bone marrow changes adjacent to the endplates as noted on magnetic resonance …
vertebral bone marrow changes adjacent to the endplates as noted on magnetic resonance …
Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population
TS Jensen, T Bendix, JS Sorensen, C Manniche… - BMC musculoskeletal …, 2009 - Springer
Background Vertebral endplate signal changes (VESC) are more common among patients
with low back pain (LBP) and/or sciatica than in people who are not seeking care for back …
with low back pain (LBP) and/or sciatica than in people who are not seeking care for back …