Chalcones are α, β unsaturated aromatic ketones having enone moiety and exhibit a wide
array of pharmaceutical and biological activities. Chalcones possess a wide range of …

Chalcones are natural substances found in the metabolism of several botanical families.
Their structure consists of 1, 3-diphenyl-2-propen-1-one and they are characterized by …

Fragment merging approach was applied for the design of thiazole/thiazolidinone clubbed
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …

Abstract Thymus algeriensis Reut & Boiss is an essential oil-bearing plant widely used in
traditional medicine to treat digestive system disorders and numerous inflammatory …

Abstract A group of 2-methyl-4-phenylquinoline-chalcone analogs (2a–2x) was synthesized
and investigated for anti-depressant, anti-inflammatory, and analgesic effects as …

Hydrazone compounds were considered as a useful moiety in drug design development.
Therefore, these studies were aimed at the synthesis of new dihydrazones and were …

An effective route for the direct synthesis of substituted pyrazole through 3+ 2 annulation
method was described.(E)-ethyl 2-benzylidene-3-oxobutanoate was prepared from ethyl …

Thirty-eight chalcone derivatives bearing a chromen or benzo [f] chromen moiety were
synthesized and evaluated for their anti-inflammatory and analgesic activities. Using an ear …

Herein we report the synthesis of a new series of aromatic sulfamates designed considering
the sulfonamide COX-2 selective inhibitors celecoxib and valdecoxib as lead compounds …

Abstract Compound 3c (5-(4-(dimethylamino) phenyl)-3-(thiophen-2-yl)-pyrazoline-1-
carbothioamide) was synthesized and characterized experimentally using UV-Vis, FT-IR …