Key Clinical Points Primary Sjögren's Syndrome A diagnosis of primary Sjögren's syndrome
is often made on the basis of a classic triad of symptoms: dryness of the mouth and eyes …

The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

Human NK cells can be subdivided into various subsets based on the relative expression of
CD16 and CD56. In particular, CD56 bright CD16−/dim NK cells are the focus of interest …

Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment …

Natural killer (NK) cells are innate lymphoid cells (ILCs) that participate to the clearance of
pathogen‐infected cells and tumour cells. NK cells and subsets of ILCs express the natural …

Both type I and II interferons (IFNs) have been implicated in the pathogenesis of Sjogren's
syndrome (SS). We aimed to explore the contribution of type I and II IFN signatures in the …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Background Mass cytometry has recently emerged as a promising tool for clinical research.
However, few studies have demonstrated its benefit for patient stratification and biomarker …

Natural killer (NK) cells have been reported to control adaptive immune responses that
occur in lymphoid organs at the early stages of immune challenge. The physiological …

Background Primary Sjogren's syndrome (pSS) is a slowly progressive, inflammatory
autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal …