Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

The ability to maintain health, or recover to a healthy state after disease, is an active process
involving distinct adaptation mechanisms coordinating interactions between all …

Objective Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing
functions in regulating plasma glucose levels, the two cell types share a common …

Major symptoms of diabetes mellitus manifest, once pancreatic β-cell numbers have become
inadequate. Although natural regeneration of β-cells after injury is very limited, bone marrow …

An important goal in diabetes research is to understand the processes that trigger
endogenous β-cell proliferation. Hyperglycemia induces β-cell replication, but the …

Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …

Cellular senescence is a response to a wide variety of stressors, including DNA damage,
oncogene activation and physiologic aging, and pathologically accelerated senescence …

Type 2 diabetes (T2D) is characterized by pancreatic beta-cell dysfunction, increased cell
death and loss of beta-cell mass despite chronic treatment. Consequently, there has been …

Genome-wide association studies have identified several gene polymorphisms, including
UBE2E2, associated with type 2 diabetes. Although UBE2E2 is one of the ubiquitin …

Maintenance of pancreatic β-cell mass and function is fundamental to glucose homeostasis
and to prevent diabetes. The PI3 K-Akt-mTORC1 pathway is critical for β-cells mass and …