Over the past four decades, the predominant view of molecular evolution saw little
connection between natural selection and genome evolution, assuming that the functionally …

We discuss the genetic, demographic, and selective forces that are likely to be at play in
restricting observed levels of DNA sequence variation in natural populations to a much …

INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present …

Chromosomal inversions have been an enduring interest of population geneticists since
their discovery in Drosophila melanogaster. Numerous lines of evidence suggest powerful …

Since the pioneering work of Dobzhansky in the 1930s and 1940s, many chromosomal
inversions have been identified, but how they contribute to adaptation remains poorly …

The extinct passenger pigeon was once the most abundant bird in North America, and
possibly the world. Although theory predicts that large populations will be more genetically …

Abstract The 'Hill–Robertson (HR) effect'describes that linkage between sites under
selection will reduce the overall effectiveness of selection in finite populations. Here we …

We report the results of a comprehensive study of the influence of gene expression on
synonymous codons, amino acid composition, and intron presence and size in human …

The constant removal of deleterious mutations by natural selection causes a reduction in
neutral diversity and efficacy of selection at genetically linked sites (a process called …

It has recently been proposed that lower mutation rates in gene bodies compared with
upstream and downstream sequences in Arabidopsis thaliana are the result of an “adaptive” …